Retine-C Complex Methylglyoxal Formula



RETINE-C Complex™ Concentrate

Carbonyl Methylglyoxal-Ascorbate Complex Formula
Based on Original Dr. Albert Szent-Gyorgi & Koch Research
BIO-IDENTICAL TO HUMAN Methylglyoxal
100% Naturally Derived from Advanced Fermentative Technology & Stabilized for Maximum Activity




Dr. Albert Szent-Gyorgyi was the Hungarian Nobel Laureate in Medicine in 1937 for the isolation and discovery of Vitamin C. He also discovered iso-flavones and vitamin P. He also researched the regulatory processes of cell growth, and the regulation of cancer. He was at the Institute for Muscle Research in Woods Hole, Massachusetts.

RETINE WAS IDENTIFIED BY NOBEL PRIZE WINNER DR.SZENT-GYORGYI IN THE 1960s . . .
RETINE (METHYLGLYOXAL) STOPS METABOLICALLY ERRANT CELLS BY BLOCKING AN ENZYME NEEDED BY THESE CELLS TO MAKE ATP FROM GLUCOSE, STARVING THEM SO THEY DIE NATURALLY (Apoptosis).

In 1963 the prestigious magazine "Science" published a remarkable article about his research. In it Dr. Szent-Gyorgyi identified two substances, one called Retine, which inhibited cancer growth, and the other called Promine, which promoted cell growth and made cancerous cells grow faster. These compounds are Ketoaldehydes and are found in the body naturally as a byproduct of the Krebs Cycle and the Glyoxylase System. His research using mice achieved shrinkage of tumors by increasing the ratio of Retine to Promine with daily injections of Retine. There were no harmful or toxic side effects.

Dr.Szent-Gyorgyi explained that he and "Dr. Egyud have found that retine (methylglyoxal) stops the growth of cancer cells without poisoning other cells. When retine is present in sufficient concentration, no cell division can occur while vital cellular processes go on unhindered." The article goes on, "And what is a good bit of luck, and not my cleverness, the white-haired scientist pointed out, "is that if a cancer cell cannot grow, it dies by itself.' According to the researchers, Retine is normally produced by the body and, when it is, it prevents the growth of existing cancer cells. But the body can lose its ability to produce this substance..."Putting the retine back in the body, just as we put insulin back into a diabetic's body, can stop the growth of cancer... The scientists at Woods Hole found that cancer cells are much more sensitive to retine than normal ones, and so cancer cells may be inhibited specifically."

Before the AAAS (American Academy of Science), April 24, 1967 he announced his work results with Methylglyoxal. He stated "We along with Dr.L. Egyud, synthesized a number of methylglyoxal derivatives...The cardinal question thus was: do tissues contain glyoxal derivatives? ... The answer was YES. "To sum up, our experiments indicate that ketone aldehydes are normal constituents of tissues and have a high biological activity. THE CHEMICAL SIGNAL WHICH REGULATES CELL DIVISION MAY THUS BE A KETONE ALDEHYDE (Methylglyoxal). These glyoxal derivates, together with the enzymes responsible for their formation and deletion, form a complex system with complex equilibria, the disturbance of which may be connected with cancer"
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RETINE is the name Szent-Gyorgyi gave Ketoaldehydes, Methylglyoxal, Glyoxal, etc.
Carbonyl's like Ketoaldehyde/Methylglyoxal arrest cell division and make cells return to a normal resting state. If Carbonyl is missing, uncontrolled proliferation goes on, and cells grow wildly and uncontrollably which leads to cancer. Glyoxal & Methylglyoxal are a non-toxic substance that is naturally found in human biochemistry. Restoring depleted levels has significant metabolic balancing effects.

MECHANISM OF ACTION DISCOVERED BY DR.MANJU RAY, et.al : ENZYME INHIBITOR
We now know from on-going research that it is an enzyme which is blocked denying access of cancer to glucose to make ATP. The enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) is required by cancer cellss and cells using glucose for energy to produce ATP. Methylglyoxal blocks this enzyme's action and without energy, the errant cells die. The cool thing is that it doesn't affect normal cells since they don't use just sugar for energy like cancer cells do. Other researchers in Europe have done research (over 200 published studies now and climbing) on this biochemistry...

DR. WILLIAM KOCH, M.D., Carbonyl Group Pioneer of the early 20th Century.
Homeopathic Carbonyl Group Catalysts of Glyoxal & Methylglyoxal
Well known Nobel Prize winner and contemporary of Dr.Szent-Gyorgyi, Dr. William Koch, worked on this same issue with a different approach. Dr. Szent-Gyorgyi acknowledged his work saying, "A decade ago, a very intuitive researcher, Dr. William F. Koch, came to the same conclusion about the possible importance of Carbonyls in regulation of cell division and carcinostasis." Koch's work was in the earlier part of the 20th Century, 1910s-1950s. He was a classical homeopathic physician and worked at U of Michigan.

Dr. Koch and Dr. Szent-Gyorgyi took different approaches to supplying methylglyoxal to the body. Dr. Szent-Gyorgyi developed a way to supplement larger quantities of methylglyoxal as a food or vitamin. Koch, being a homeopathic doctor, preferred to make it homeopathically to stimulate the body's own production. Both methods work but used together may be ideal.
Koch Methylglyoxal Homeopathic Catalysts
Made in the USA !

NEW RETINE-C COMPLEX™ CONCENTRATE -- Technology Breakthrough Produces a Highly Active, Biologically Available & Stable Methylglyoxal + Vitamin C Complex for the first time ever...

Advances in organic and biomolecular chemistry have yielded some incredible new products to help maintain health and this is one of them. Our chemist has been able to use advanced fermentation technologies to successfully produce a toxin-free Stabilized Methylglyoxal compound bound together with L-Ascorbate (buffered C) to yield a very active stable compound. Traditionally methylglyoxal has been available alone and one had to take Vitamin C supplements with it. With the new technology, is no longer necessaary since it is bound right into it. It actually is a catalyzed compound which is very active. A low strength Multi-B vitamin needs to be taken twice daily to enhance Liver detox antioxidant enzymes. We also recommend several times a week for at least 10 min. to do some mild exercize like Oxycize (Oxycise.com) or to breath 100% pure oxygen at a very low flow while gently moving vertically on a rebounder like trampolinc (EWOT) in order to increase tissue oxygenation & lymphatic movement which will enhance uptake by the cells of the product and and facilitate detox of dead cellular debris. If exercise is impossible, then a good massage several times a week to move the lymph.

QUESTIONS & ANSWERS :

How is your product different?
1. Ours is a pure concentrate combined with Vitamin C as a complex. It is not plain old methylglyoxal. It is not a powder or homeopathic vial. The manufacture is controlled from raw material analysis & procurement to the finished product all done in-house here in the USA in a GMP certified Lab.
2. All raw materials (plant based) are the highest GMP quality.
3. Our methylglyoxal complex is made 100% by hand in small batches from scratch using high tech fermentative and ultrasonic technologies. Absolutely no toxic byproducts are in it since there is no chemical commercial methylglyoxal in our product. We certify it free of formaldehyde, ethylalcohol, pyruvate, lactate, formate.
4. Our product is a Bio-Identical molecularly to human methylglyoxal, which declines naturally with age. It is highly bioavailable and has shown no toxicity.
5. Our patent-pending product is the ONLY product worldwide which is stabilized and bonded with L-Ascorbate molecule to retain its highly active state.
6. Each batch is painstakenly made by hand every 2 weeks. It is not a mass-manufactured product and the batch size varies with demand.
Are there any Side Effects?
No, none known. The compound looks like water with a sight fizz and tartness. It is very mild and blends into any drink (except milk) or may be taken alone in water. Remember it is a normal constituent of the body. Some researchers using a non-modified basic off-the-shelf chemical form which contained toxic byproducts (which is NOT our product) found kidney damage in mice...See Toxicity Issus discussion below. On-going clinical research shows that inside the human body (in-vivo) this is not an issue at all.
What Kind of Results Are You Getting ?
Too early to tell. This is a Brand New product, we haven't collected any data yet. It is not patentable so no pharmaceutical company will underwrite it, so we're looking for private investor funding. We're currently getting ready to do som outcome studies through Europa Institute of Integrated Medicine in Tijuana, our affiliate Cancer Clinic. Under agreement from our manufacturer, we're giving a month supply free to a limited amount of patients who qualify for our study in exchange for collection and publication of the data. Call Dr.Bormann to apply for candidacy for the study if interested.
Where is it available?
It is not widely distributed currently. We're a direct authorized manufacturer's rep. It will NOT be sold to healthfood stores or MLMs or retailers but only to qualified professionals we have carefully chosen since users need to be monitored if they are dealing with serious conditions. It is sold as a nutritional supplement to replenish the body's methylglyoxal stores.
What about toxicity ?
There are over 200 research articles published over the years on this substance. Methylglyoxal as a chemical is available in a commercial chemical form from a few chemical companies for commercial uses, etc. The chemical manufacturing for off-the-shelf methylglyoxal leaves toxic byproducts and should never be used by humans... it contains known carcinogens i.e. formaldehyde, ethyl alcohol, pyruvate, lactate, formate. In fact, the amount of formaldehyde can account sometimes for as much of 30% of these solutions ! WE USE ABSOLUTELY NO COMMERCIAL CHEMICAL METHYLGLYOXAL IN OUR PRODUCT. Ours is made from scratch directly through highly controlled fermentative processes using plant materials, in a GMP FDA certified Lab IN THE USA. Our product is certified free of any toxic chemical byproducts. The patented process is the result of 3 years of concentrated research to develop a cost effective minimally processed product WHICH PRODUCES A BIOIDENTICAL MOLECULE, AND WHICH IS STABILIZED TO RETAIN IT'S ACTIVITY.
Is it Expensive?
We are currently selling it for $185.00 per 960 ml bottle,which is a one-month supply. Other MG products range from $250-$300 per pint (8 oz.) or as a powdered drink which is weak and does NOT have vitamin C bound to it. We're a direct authorized Rep. for the Chemist for several products and so there is no middle-man. Individuals willing to give us on-going case information so we can determine effectiveness will be given a discount in exchange for their continued information, up to 3 mos. supply.
Return Policy:
Due to the specialized nature of this product, all sales are final. There are absolutely no returns or refunds. We will exchange bottles verified damaged in shipping and returned immediately w/photo if the customer calls us to notify us so we can put in a loss claim with the carrier. Bottles which have not been kept refrigerated or are damaged by the customer from misuse will not be elligible for return.
Special Overnight Shipping Required Due to Mandatory Refrigeration Need:
Because we need to keep the product refrigerated to maintain stability, we will only ship Guaranteed Overnight Insured with Signature Required since it is crucial the product be refrigerated immediately to help insure it's activity. This is more expensive and we apologize but this is the requirement of our chemist. Cost for this type of shipping service will vary depending on the carrier.


RECENT RESEARCH & CLINICAL STUDIES




There has been encouraging work done in Calcutta, India by Prof. Manju Ray (photo at left) who continues to do on-going research. She recently published a study with terminal cancer patients in which the overall results were quite encouraging. (Note: this is on end-stage patients who had undergone chemotherapy, surgery, radiation, etc.) The formula Dr.Ray used is not the same as ours but much simpler. We continue to exchange information with her.
cancer.html







USES:

Cancer Therapy Adjunctive under qualified physician monitoring

Anti-viral / Immune Therapy (Koch used it as an antiviral therapy in homeopathic form)

Anti-fungal therapy since it starves fungus (fungi/yeast use sugar only for food just like cancer cells do...)

Pain management (Analgesic)

Helps Reduce Blood Pressure (Hypotensive)


Retine-C Complex Concentrate is Highly Active & Bioavailable
It is a Stabilized Complex, the first of its kind in the world
Made from scratch with Advanced Fermentative Technology in High Controlled GMP Lab in the USA.
Bio-Identical to Human MG
Helps maintain homeostasis by Replenishing Retine / Methylglyoxal levels which decline with age
Absolutely NO toxic contaminants, additives, etc.
Direct Manufacturer Rep.so eliminates any middlemen...

SUPPLEMENT FACTS
Size: 960 ml. (1 qt.) Concentrate
Serving Size: 8 ml.(1.25 tsp) in 2 oz. water (approx. 30 mg./kilo bodyweight)
# Servings per Bottle: 120, a 30 day supply
Contains: Proprietary mix of Distilled Water, Retine-C Complex Concentrate
Certified Free of Pyruvates, Formaldehydes, Ethyl alcohol, Lactate, Formate
No added preservatives or allergens like soy, glutens, corn, dairy, etc.
A slight fizz and tartness is normal on opening.

Instructions: Take 8 ml.( 1.5 tsp) in 2 oz. water or juice 4 times daily. Taking it consistently is important. Take 5 days on, 2 off. Critical to take a low strength multi-B vitamin twice daily to provide added antioxidant protection for the liver enzymes and to help facilitate detoxification pathways.

IMPORTANT NOTE: To Reduce Liver Stress as it detoxifies cellular debris, we recommend eating absolutely no animal protein products (for at least 10 days). After that, small amounts of high quality yogurt, free range organic eggs, chicken, turkey, fish are OK. Stay away from red meats and cured foods with nitrates and ALL SOY products.

REFRIGERATE IMMEDIATELY AND KEEP LIGHT FREE. (Vitamin C is deactivated by Light)

CAUTION: Not for use by Pregnant Women, Type I Diabetics. Individuals with serious conditions should use under qualified physician monitoring. Keep Away from Children. Discontinue if adverse effects occur.

Mandatory FDA Disclaimer: The statements & products shown on this website have not been evaluated by the US Food and Drug Administration. Statements are not intended to constitute professional advice for treatment of any disease but are for educational purposes. These products are not intended to diagnose, treat, cure or prevent any disease.

Packaging: Brown Plastic 1000 cc PET Bottles
Price per bottle: $185.00 ea. + S & H. Shipped Insured Overnight.
Due to hand made high quality manufacturing methods in small batches and the fact that it has a 3-6 mo. shelf life, we don't recommend buying more than 2 at a time.
We'll notify you if we're backordered. All orders are prepaid. This is a special order item.


SPECIAL PACKING & SHIPPING REQUIRED. DRY ICE IS USED IN WARM WEATHER, IN INSULATED COLD PAK BOXES.
SHIPPING IS OVERNIGHT, INSURED (Depending on currier, "overnight" rarely means overnight these days. Even guaranteed overnight isn't always possible but generally 1-2 business days for most parts of the US).

NOTE: THOSE WHO ARE ABLE TO PARTICIPATE IN OUR STUDY (LIMITED NUMBER) WILL NOT BE CHARGED FOR THE FIRST BOTTLE ITSELF, HOWEVER THEY NEED TO PAY FOR THE COST OF SHIPPING & INSURANCE WHICH VARIES WITH LOCATION & CARRIER.

THE PRODUCT MUST STAY REFRIGERATED.

ALL SALES FINAL. NO RETURNS OR REFUNDS. EXCHANGE ONLY FOR SHIPPING DAMAGE.
Research Citations & Abstracts on Methylglyoxal / Retine
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Science 7 June 1968: Vol. 160. no. 3832, p. 1140 DOI: 10.1126/science.160.3832.1140
Cancerostatic Action of Methylglyoxal
Laszlo G. Együud and Albert Szent-Györgyi
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http://www.jstor.org/pss/67257
The Living State and Cancer
Albert Szent-Gyorgyi, Ph.D.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 7 (Jul., 1977), pp. 2844-2847
Published by: National Academy of Sciences
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PUBMED Listing of Szent-Gyorgyi's research publications. Several on Retine & Methylglyoxal
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=Szent-Gyorgyi A[au]&dispmax=50
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National Library of Medicine Szent-Gyorgyi Papers
national.html
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Nature 209, 1346 - 1347 (26 March 1966); doi:10.1038/2091346b0
Chemical Nature of Free Retine, an Anti-tumour Agent
CLAUDE MARMASSE
9, Quai de l'Abbé Grégoire, Blois, France.
THE wide distribution of natural anti-tumour agents has been shown by Szent-Györgyi et al. 1 and many others. There is, notably, such a compound in human urine, which has been called retine and has been previously isolated by Hegyeli et al. 2. This compound has a molecular weight of approximately 430 (ref. 3) and induces a significant regression of Krebs-2 carcinoma in Swiss albino mice. Treatment of retine with hot acetic acid releases a compound which is responsible for the anti-tumour activity 4.
1. Szent-Györgyi, A. , Hegyeli, A. , and McLaughlin, J. , Proc. U.S. Nat. Acad. Sci., 49, 878 (1963). 2. Hegyeli, A. , McLaughlin, J. , and Szent-Györgyi, A. , Science, 142, 1571 (1963). | PubMed | ISI | ChemPort | 3. Marmasse, C. , Hegyeli, A. , and King, A. (to be published). 4. Hegyeli, A. (personal communication). 5. Jaffe, H. , and Orchin, M. , Theory and Application of Ultraviolet Spectroscopy (Wiley, New York, 1962). 6. Karrer, P. , Organic Chemistry, fifth English ed. (Elsevier, Amsterdam, 1950). 7. Dashkevich, L. , and Sirraya, V. , Zh. Obshch. Khim., 32, 2330 (1962). (See Chem. Abs., 58, 7946; 1963.) | ISI | ChemPort | 8. Krepelka, J. , and Vebersik, V. , Chem. Listy, 43, 25 (1949). (See Chem. Abs., 44, 9565; 1950.) | ISI | ChemPort |
Treatment of a number of cancer patients suffering from different types of malignancies by methylglyoxal-based formulation: A promising result
Dipa talukdar, Subhankar Ray, Sanjoy Das, Ashok Kumar Jain, Arvind Kulkarni, Manju Ray
Dept. of Biochemical Chemistry, Indian Association for Cultivation of Science, Jadavpur, Calcutta, India. SVS Marwari Hospital, Calcutta, Lokmanya Medical Research Centre, Chinchwad, Pune India
Cancer Therapy Vol 4, 205-222, 2006
"Abstract : Based on our previous in vitro studies with human cells and in vivo studies with animals we had developed an anticancer formulation with methylglyoxal as the lead ingredient. This formulation has a tumoricidal effect by inhibiting specifically in cancerous cells the electron flow and the transfer of reducing equivalent necessary for the production of adenosine-5¢ -triphosphate, the cellular energy currency. By keeping this remarkable property in mind, we had treated 24 patients suffering from different types of malignancy (mostly in very advanced stage of the disease) with this methylglyoxal-based formulation. The results indicate a dramatic positive effect on the patients. Out of the 24 patients, 11 are in excellent physical condition, the condition of 5 patients can be considered stable. The rest had either opted out from the treatment or died during the course of the study. These results strongly suggest that this formulation is by far more superior than other present forms of treatment against cancer. It is imperative that this formulation be widely used in treating cancer patients, as well as to attempt the improvement of its efficacy. "

Med Hypotheses. 1997 Jun;48(6):473-6. Related Articles, Links
Does excessive adenosine 5'-triphosphate formation in cells lead to malignancy? A hypothesis on cancer.
Ray S, Ray M., Department of Biochemistry, University College of Science, University of Calcutta, India.
In biological systems, adenosine triphosphate (ATP) is the principal contributor of free energy necessary for anabolic reactions and is also a precursor of nucleic acids. Moreover, active transport of metabolites into cells is also driven by hydrolysis of ATP. So, a cell may grow, multiply and ultimately turn malignant when it has been transformed in such a manner that it produces excess ATP as compared with its usual metabolic demand. Recent studies have indicated that mitochondrial complex I and the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) may be critically altered specifically in malignant cells. So, we further propose that this excessive ATP formation may be due to altered mitochondrial complex I and GA3PD of malignant cells.
PMID: 9247887 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9247887

Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal.
Biswas S, Ray M, Misra S, Dutta DP, Ray S.
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta 700 032, India.
The effect of methylglyoxal on the oxygen consumption of mitochondria of both normal and leukaemic leucocytes was tested by using different respiratory substrates and complex specific artificial electron donors and inhibitors. The results indicate that methylglyoxal strongly inhibits mitochondrial respiration in leukaemic leucocytes, whereas, at a much higher concentration, methylglyoxal fails to inhibit mitochondrial respiration in normal leucocytes. Methylglyoxal strongly inhibits ADP-stimulated alpha-oxoglutarate and malate plus NAD+-dependent respiration, whereas, at a higher concentration, methylglyoxal fails to inhibit succinate and alpha-glycerophosphate-dependent respiration. Methylglyoxal also fails to inhibit respiration which is initiated by duroquinone and cannot inhibit oxygen consumption when the N,N,N', N'-tetramethyl-p-phenylenediamine by-pass is used. NADH oxidation by sub-mitochondrial particles of leukaemic leucocytes is also inhibited by methylglyoxal. Lactaldehyde, a catabolite of methylglyoxal, can exert a protective effect on the inhibition of leukaemic leucocyte mitochondrial respiration by methylglyoxal. Methylglyoxal also inhibits l-lactic acid formation by intact leukaemic leucocytes and critically reduces the ATP level of these cells, whereas methylglyoxal has no effect on normal leucocytes. We conclude that methylglyoxal inhibits glycolysis and the electron flow through mitochondrial complex I of leukaemic leucocytes. This is strikingly similar to our previous studies on mitochondrial respiration, glycolysis and ATP levels in Ehrlich ascites carcinoma cells [Ray, Dutta, Halder and Ray (1994) Biochem. J. 303, 69-72; Halder, Ray and Ray (1993) Int. J. Cancer 54, 443-449], which strongly suggests that the inhibition of electron flow through complex I of the mitochondrial respiratory chain and inhibition of glycolysis by methylglyoxal may be common characteristics of all malignant cells.
Biochem J. 1997 Apr 15;323 ( Pt 2):343-8. Related Articles, Links
Similar nature of inhibition of mitochondrial respiration of heart tissue and malignant cells by methylglyoxal. A vital clue to understand the biochemical basis of malignancy. Ray S, Biswas S, Ray M.
Department of Biochemistry, University College of Science, University of Calcutta, India.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9201701
Mol Cell Biochem. 1997 Jun;171(1-2):95-103. Related Articles, Links

Implication of bioelectronic principle in cancer therapy : treatment of cancer patients by methylglyoxal - based formulation. Manju Ray, Swapna Ghosh, Manoj Kar, Santajit Datta, Subhankar Ray Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta 700 032, India.
(2001) Indian Journal of Physics, 75B. No2, 73-77

Effects of methylglyoxal on platelet hydrogen peroxide accumulation, aggregation and release reaction.
Leoncini G, Poggi M.
Istituto Policattedra di Chimica Biologica, Universita di Genova, Italy
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8640957
Cell Biochem Funct. 1996 Jun;14(2):89-95. Related Articles, Links
Mol Cell Biochem. 1997 Dec;177(1-2):21-6. Related Articles, Links
Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal.Ray M, Basu N, Ray S.
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9450641

MADE IN THE U.S.A. !

Mandatory FDA Disclaimer: The statements & products shown on this website have not been evaluated by the US Food and Drug Administration. Statements are not intended to constitute professional advice for treatment of any disease but are for educational purposes. These products are not intended to diagnose, treat, cure or prevent any disease.


(909) 338-3533 / FAX (909) 338-3743
E-mail: dbormann@arrowheadhealthworks.com *ARROWHEADHEALTHWORKS.COM